The Red Devils are hoping to secure a victory that will move them five points clear of Liverpool in the Premier League table, as the pair fight to finish runners-up to Manchester City at the end of 2017/18.
Many expect Mourinho to park the bus against Jurgen Klopp's brilliantly offensive Liverpool side, as he does not want to run the risk of United being torn apart by the Reds.
The Portuguese has built a reputation for approaching games against big teams in a defensive manner, but how does Mourinho's record against the Premier League big six actually look?
Click the right arrow, above, to see Mourinho's record against the top six clubs, ranked by the points per game won against every opponent...
*Only fixtures played in the Premier League are included. All data correct as of March 9, 2018