Arguably English football’s greatest rivalry, the 200th meeting between these English heavyweights promises to be an intriguing affair.
The Reds are in blistering form at the moment, with Mohamed Salah seemingly breaking a different goal-scoring record every time he sets foot on the pitch.
Conversely, there is tension surrounding Jose Mourinho’s side with disgruntled fans wanting more from his glittering collection of superstars.
While neither side can realistically expect to catch runaway leaders Manchester City, there is still so much on the line between these two.
United are just two points ahead of the Reds in third, but this is a game with so much pride at stake.
But which side has the upper hand in recent games?
Click on the right arrow, above, to see a review of the previous ten Premier League games between these rivals.