One of O.J. Simpson's former BFFs is giving his alleged big-screen return 2 thumbs down -- telling TMZ Sports there ain't a chance Juice gets loose in Hollywood again.
Ahmad also told us there's no way in hell he'd watch Sacha's flick if O.J.'s in it (shocker).
FYI, Simpson's Hollywood credits include blockbusters like "Roots" and "The Naked Gun" trilogy.